Cultivation of human embryonic liver cells in disposable microplates.

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Cultivation of human embryonic liver cells in disposable microplates.

Zuckerman, Tsiquaye, and Fulton in 1967 described a method for the cultivation of monolayers of differentiated parenchymal human embryonic liver cells in glass tissue culture plates made especially for this purpose. The apparatus utilized and the precise method of implantation are given in detail by Fulton (1960). This technique was later modified and extended to the culture of very small fragm...

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Differentiation of human embryonic stem cells into neurons

Human embryonic stem (ES) cells are undifferentiated pluripotent cells derived from the inner cell mass of blastocyst stage embryos. These unique cell lines have the potential to form virtually any cell type in the body and can be propagated in vitro indefinitely in an undifferentiated state. These cells are capable of forming embryoid bodies (EB) that contain cells from all three embryonic lin...

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Differentiation of human embryonic stem cells into neurons

Human embryonic stem (ES) cells are undifferentiated pluripotent cells derived from the inner cell mass of blastocyst stage embryos. These unique cell lines have the potential to form virtually any cell type in the body and can be propagated in vitro indefinitely in an undifferentiated state. These cells are capable of forming embryoid bodies (EB) that contain cells from all three embryonic lin...

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Human non-parenchymal liver cells for co-cultivation systems

Recently, Pfeiffer and colleagues have published protocols that allow the isolation of human hepatocytes and non-parenchymal liver cells from the same donor (Pfeiffer et al., 2014). Cell isolation is performed with resected liver tissue, usually obtained from hepatectomy because of metastasis from colon cancer. Human liver cells are initially isolated by the conventional two-step EDTA/ collagen...

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Expression of Endoderm and Hepatic Specific Genes after in vitro Differentiation of Human Embryonic Stem Cells

Background: Human embryonic stem cells (hESC), which are derived from the inner cell mass of the blastocysts, have been considered to be pluripotent cells. In this study we examine the differentiating potential of hESC into hepatocytes by characterization of the expression of endoderm and liver-specific genes. Methods: hESC were cultivated in suspension to form aggregates, the embryoid bodies. ...

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ژورنال

عنوان ژورنال: Journal of Clinical Pathology

سال: 1972

ISSN: 0021-9746

DOI: 10.1136/jcp.25.4.362